SCHEMBL11054644

SCHEMBL11054644

O=C(Nc1ccccc1)Nc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 5/20 0.74
EPHX1 P07099 2/20 0.74
EPHX2 P34913 2/20 0.74
SMN1; SMN2 Q16637 2/20 0.74
TP53 P04637 1/20 0.74
TSHR P16473 1/20 0.74
CDK9 P50750 1/20 0.74
CLK4 Q9HAZ1 1/20 0.74
KMT2A Q03164 7/20 0.71
MEN1 O00255 6/20 0.71
RAB9A P51151 6/20 0.71
MAPT P10636 3/20 0.71
NPSR1 Q6W5P4 1/20 0.71
CASP3 P42574 1/20 0.69
SENP7 Q9BQF6 1/20 0.69
NPC1 O15118 5/20 0.69
HTT P42858 3/20 0.69
LMNA P02545 2/20 0.69
MAOA P21397 2/20 0.67
MAOB P27338 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4105004 1.00 CNR1 (0.74) CNR1EPHX1EPHX2SMN1; SMN2TP53
SCHEMBL23069098 0.92 ALDH1A1 (0.68) CNR1EPHX1EPHX2SMN1; SMN2TP53
SCHEMBL11048619 0.91 MEN1 (0.76) CNR1EPHX1EPHX2SMN1; SMN2TSHR
SCHEMBL4741253 0.91 MEN1 (0.76) CNR1EPHX1EPHX2SMN1; SMN2TSHR
SCHEMBL20557568 0.90 CNR1 (0.81) CNR1ALDH1A1
SCHEMBL21295544 0.89 MAPT (0.67) CNR1EPHX1EPHX2SMN1; SMN2TP53
SCHEMBL19501649 0.89 SIRT1 (0.77) CNR1SMN1; SMN2KMT2AMEN1RAB9A
SCHEMBL11059378 0.89 SMN1; SMN2 (0.94) EPHX1EPHX2SMN1; SMN2TP53TSHR
SCHEMBL6552789 0.87 PTGS2 (0.62) CNR1EPHX1EPHX2SMN1; SMN2TP53
SCHEMBL20557858 0.86 CNR1 (1.00) CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4444863-A UREA COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1984-04-24 US disclosed