Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.49 |
| ▸ | THRA | P10827 | 5/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333097 | 0.90 | THRB (0.39) | THRBTHRAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL5328035 | 0.90 | THRB (0.42) | THRBTHRACNR2HSD17B10KDM4E | |
| SCHEMBL5324532 | 0.84 | THRB (0.65) | THRBTHRAKDM4EALDH1A1HPGD | |
| SCHEMBL5328690 | 0.81 | THRB (0.44) | THRBTHRACNR2HSD17B10KDM4E | |
| SCHEMBL1642315 | 0.81 | THRB (0.74) | THRBTHRA | |
| SCHEMBL5331470 | 0.80 | KMT2A (0.39) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7043128 | 0.78 | THRB (0.42) | THRBTHRACNR2HSD17B10KDM4E | |
| SCHEMBL3222490 | 0.78 | THRB (0.44) | THRBTHRACNR2HSD17B10KDM4E | |
| SCHEMBL5327228 | 0.76 | THRB (0.42) | THRBTHRA | |
| SCHEMBL6662999 | 0.75 | THRB (0.50) | THRBTHRACNR2HSD17B10EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007132475-A1 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2007-11-22 | — | — | WO | claimed |
| WO-2007132475-A1 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2007-11-22 | — | — | WO | disclosed |