Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5331844 | 0.88 | HTR6 (0.56) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL5331965 | 0.84 | HTR6 (0.67) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL5304701 | 0.84 | HTR6 (0.49) | HTR6PPARGPPARDPPARA | |
| SCHEMBL5327454 | 0.81 | HTR6 (0.58) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL5324133 | 0.78 | HTR6 (0.57) | HTR6 | |
| SCHEMBL945681 | 0.77 | HTR6 (0.76) | HTR6PPARGPPARDPPARA | |
| SCHEMBL947469 | 0.76 | HTR6 (0.74) | HTR6PPARGPPARDPPARA | |
| SCHEMBL5332694 | 0.75 | HTR6 (0.49) | HTR6DRD2HTR7 | |
| SCHEMBL945661 | 0.74 | KDM4E (0.76) | HTR6CA2CA9MEN1KMT2A | |
| SCHEMBL30542060 | 0.74 | KDM4E (0.76) | HTR6CA2CA9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007020653-A1 | THIOETHER DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-02-22 | — | — | WO | disclosed |