Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319750 | 0.85 | MEN1 (0.41) | KMT2AMEN1HDAC6LMNAMAPT | |
| SCHEMBL7971128 | 0.85 | ALDH1A1 (0.43) | KMT2AMEN1EGFRSRCLMNA | |
| SCHEMBL5325316 | 0.80 | SMN1; SMN2 (0.43) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL5320461 | 0.78 | BLM (0.38) | KMT2AMEN1NPC1 | |
| SCHEMBL1528022 | 0.78 | KMT2A (0.44) | KMT2AMEN1EGFRLMNATP53 | |
| SCHEMBL8806580 | 0.78 | KMT2A (0.44) | KMT2AMEN1LMNAMAPT | |
| SCHEMBL6446028 | 0.76 | KMT2A (0.43) | KMT2AMEN1CYP1A2CYP2C19MAPT | |
| SCHEMBL8806973 | 0.75 | KMT2A (0.42) | KMT2AMEN1 | |
| SCHEMBL4759513 | 0.75 | KMT2A (0.42) | KMT2AMEN1MAPT | |
| SCHEMBL27544681 | 0.75 | KMT2A (0.41) | KMT2AMEN1EGFRLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |