Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170659 | 0.88 | TBXAS1 (0.41) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL7971128 | 0.88 | ALDH1A1 (0.43) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL5319750 | 0.83 | MEN1 (0.41) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL5320461 | 0.81 | BLM (0.38) | POLBMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL27032230 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP4F2CYP4A11POLBLMNA | |
| SCHEMBL5328017 | 0.80 | KMT2A (0.40) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL27032634 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP4F2CYP4A11POLBLMNA | |
| SCHEMBL8806580 | 0.79 | KMT2A (0.44) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL1564315 | 0.77 | TSHR (0.41) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL7868637 | 0.77 | HSP90AA1 (0.52) | SMN1; SMN2MAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |