Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 4/20 | 0.34 |
| ▸ | CDK8 | P49336 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454557 | 0.88 | LMNA (0.38) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL4469392 | 0.83 | MAPT (0.36) | LMNACYP1A2CYP3A4MAOAPDE4D | |
| SCHEMBL12616797 | 0.76 | TP53 (0.41) | CYP3A4TSHRTP53SMN1; SMN2MAPT | |
| SCHEMBL2312114 | 0.74 | CCNC (0.36) | LMNACYP3A4PRKCZCCNCCDK8 | |
| SCHEMBL2603861 | 0.72 | CYP3A4 (0.38) | CYP1A2CYP3A4TSHRTP53SMN1; SMN2 | |
| SCHEMBL12071514 | 0.69 | MET (0.36) | LMNAPDE4DMEN1KMT2AALDH1A1 | |
| SCHEMBL11444462 | 0.68 | LMNA (0.59) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL4469381 | 0.68 | RAB9A (0.44) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL12434472 | 0.68 | CDC25B (0.37) | LMNATSHRNPC1RAB9ATP53 | |
| SCHEMBL22473756 | 0.67 | CYP1A2 (0.49) | LMNACYP1A2CYP3A4MAOAPRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812433-A1 | IMIDAZO[4,5-B]PYRIDIN-2-ONE AND OXAZOLO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC COMPOUNDS | Cancer Research Technology Limited (GB) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006043090-A1 | IMIDAZO[4,5-B]PYRIDIN-2-ONE AND OXAZOLO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |