Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.48 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332897 | 0.89 | HTR6 (0.51) | HTR6PTGDR2PTGDRALDH1A1LMNA | |
| SCHEMBL5331543 | 0.89 | PCSK9 (0.46) | HTR6CXCL8NOD1ALDH1A1HTT | |
| SCHEMBL5327664 | 0.88 | HTR6 (0.47) | HTR6LMNAHTTPKM | |
| SCHEMBL5326308 | 0.87 | NOD1 (0.45) | HTR6NOD1ALDH1A1LMNATSHR | |
| SCHEMBL5336637 | 0.87 | HTR6 (0.48) | HTR6NOD1PTGDR2PTGDRLMNA | |
| SCHEMBL5327986 | 0.86 | HTR6 (0.52) | HTR6PTGDR2PTGDRALDH1A1LMNA | |
| SCHEMBL5425727 | 0.85 | PTGDR2 (0.56) | HTR6PTGDR2PTGDRLMNA | |
| SCHEMBL5331999 | 0.85 | HTR6 (0.51) | HTR6PTGDR2PTGDR | |
| SCHEMBL5327663 | 0.85 | HTR6 (0.49) | HTR6ALDH1A1LMNATSHRHTT | |
| SCHEMBL5331610 | 0.84 | HTR6 (0.52) | HTR6PTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007020653-A1 | THIOETHER DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-02-22 | — | — | WO | claimed |
| WO-2007020653-A1 | THIOETHER DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-02-22 | — | — | WO | disclosed |