Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | AURKA | O14965 | 7/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 4/20 | 0.49 |
| ▸ | PRKCA | P17252 | 4/20 | 0.49 |
| ▸ | CDK4 | P11802 | 3/20 | 0.49 |
| ▸ | CCND1 | P24385 | 3/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.49 |
| ▸ | PRKCG | P05129 | 3/20 | 0.49 |
| ▸ | PRKCH | P24723 | 3/20 | 0.49 |
| ▸ | PRKCI | P41743 | 3/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30775231 | 0.73 | AURKA (0.61) | KDRAURKAPARP1CDK1CA12 | |
| SCHEMBL1202543 | 0.72 | IMPDH2 (0.63) | PRKCBPRKCACDK4CCND1PRKD3 | |
| SCHEMBL8167094 | 0.72 | CDK4 (0.68) | KDRAURKAPRKCBPRKCACDK4 | |
| SCHEMBL28476173 | 0.71 | CA1 (0.51) | PRKCBPRKCACDK4CCND1PRKD3 | |
| SCHEMBL5328900 | 0.71 | AURKA (1.00) | KDRAURKAPARP1CDK1CDK2 | |
| SCHEMBL5333071 | 0.70 | KDR (1.00) | KDRAURKAPARP1CDK1CA12 | |
| SCHEMBL6016048 | 0.70 | PRKCB (0.44) | PRKCBPRKCACDK4CCND1PRKD3 | |
| SCHEMBL10438759 | 0.70 | SIRT2 (0.58) | PRKCBPRKCACDK4CCND1PRKD3 | |
| SCHEMBL28000551 | 0.70 | AURKA (0.75) | KDRAURKAPARP1CDK1CA12 | |
| SCHEMBL743601 | 0.69 | PARP1 (1.00) | KDRAURKAPARP1PIM1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161648-A1 | Substituted dihydro-isoindolones useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-12 | — | — | US | claimed |
| WO-2007047646-A2 | SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-26 | — | — | WO | claimed |
| US-20070161648-A1 | Substituted dihydro-isoindolones useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161648-A1 | Substituted dihydro-isoindolones useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161648-A1 | Substituted dihydro-isoindolones useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-12 | — | — | US | disclosed |
| WO-2007047646-A2 | SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007047646-A2 | SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161648-A1 | Substituted dihydro-isoindolones useful in treating kinase disorders | MAP3K20, MAP3K3, MAP3K19 | KDR 1627/4885AURKA 669/4885PARP1 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.