Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369447 | 0.87 | PFKFB3 (0.71) | PGRKMT2AMEN1MAPTPKM | |
| SCHEMBL29875309 | 0.87 | PFKFB3 (0.71) | PGRKMT2AMEN1MAPTPKM | |
| SCHEMBL2831061 | 0.87 | PFKFB3 (0.71) | PGRKMT2AMEN1MAPTPKM | |
| SCHEMBL2828714 | 0.86 | MEN1 (0.74) | PGRKMT2AMEN1LMNAMAPT | |
| SCHEMBL664321 | 0.85 | KMT2A (0.75) | PGRKMT2AMEN1PKM | |
| SCHEMBL7366821 | 0.85 | AKR1C3 (0.67) | PGRKMT2AHDAC2HDAC8HDAC6 | |
| SCHEMBL3756876 | 0.84 | PGR (1.00) | PGRKMT2AMEN1LMNAMAPT | |
| SCHEMBL8251165 | 0.84 | PFKFB3 (0.67) | PGRKMT2AMEN1LMNAMAPT | |
| SCHEMBL7373685 | 0.84 | KMT2A (0.68) | PGRKMT2AHDAC2HDAC8HDAC6 | |
| SCHEMBL4813023 | 0.83 | HDAC3 (0.70) | PGRKMT2AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144379-A1 | BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS | MEDIVIR AB (SE) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007144379-A1 | BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS | MEDIVIR AB (SE) | 2007-12-21 | — | — | WO | disclosed |