Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 5/20 | 0.64 |
| ▸ | CLK1 | P49759 | 3/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | FADS1 | O60427 | 1/20 | 0.57 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIF5B | P33176 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5468355 | 0.99 | EGFR (0.64) | MEN1KMT2AEGFRCLK1ABCG2 | |
| SCHEMBL5313058 | 0.87 | EGFR (0.66) | EGFRLCKFADS1PIP4K2CDYRK1A | |
| SCHEMBL7892367 | 0.87 | ABCG2 (0.53) | MEN1KMT2AEGFRCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL7892323 | 0.86 | ABCG2 (0.52) | MEN1KMT2AEGFRCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL5463170 | 0.86 | EGFR (0.65) | EGFRLCKFADS1PIP4K2CDYRK1A | |
| SCHEMBL5468539 | 0.82 | PIP4K2C (0.64) | MEN1KMT2AEGFRCLK1LCK | |
| SCHEMBL5463906 | 0.82 | EGFR (0.49) | MEN1KMT2AEGFRCLK1ABCG2 | |
| SCHEMBL7122741 | 0.81 | PIP4K2C (0.62) | MEN1KMT2AEGFRCLK1LCK | |
| SCHEMBL5314379 | 0.81 | EGFR (0.56) | MEN1KMT2AEGFRCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL5467050 | 0.81 | PIP4K2C (0.62) | MEN1KMT2AEGFRCLK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056215-A9 | N-ARYL-THIENOPYRIMIDIN-4-AMINES AND THE USE THEREOF | CYTOVIA INC (US) | 2007-09-13 | — | — | WO | claimed |
| WO-2007056215-A2 | N-ARYL-THIENOPYRIMIDIN-4-AMINES AND THE USE THEREOF | CYTOVIA, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-05-03 | — | — | US | claimed |
| US-20070213305-A1 | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213305-A1 | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP10, CASP4, CASP3 | MEN1 1674/4885KMT2A 2940/4885EGFR 1334/4885 |
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP4, CASP3, API5 | MEN1 1984/4885KMT2A 3038/4885EGFR 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.