Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528199 | 0.94 | HTR1A (0.50) | RAB9AHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL4526590 | 0.93 | HTR1A (0.49) | RAB9AHTR1ADRD2HTR7 | |
| Cadaverine Tartrate SCHEMBL5326038 | 0.93 | RAB9A (0.48) | RAB9AHTR1ADRD2HTR7ADRA1B | |
| Phosphoric Acid SCHEMBL5337828 | 0.91 | HTR1A (0.47) | RAB9AHTR1ADRD2HTR7 | |
| Succinic Acid SCHEMBL5297213 | 0.89 | HTR1A (0.39) | RAB9AHTR1ADRD2HTR7ABCB1 | |
| SCHEMBL4535208 | 0.84 | DRD2 (0.50) | HTR1ADRD2HTR7ADRA1B | |
| Succinic Acid SCHEMBL5327295 | 0.84 | HTR1A (0.38) | HTR1ADRD2HTR7 | |
| SCHEMBL4537694 | 0.83 | HTR1A (0.42) | RAB9AHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL4528897 | 0.82 | HTR1A (0.43) | RAB9AHTR1ADRD2HTR7 | |
| Cadaverine Tartrate SCHEMBL5331439 | 0.82 | HTR1A (0.39) | RAB9AHTR1ADRD2HTR7ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |