Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328948 | 0.85 | ALDH1A1 (0.63) | ALDH1A1MAPTKDM4EKMT2ATSHR | |
| SCHEMBL5332752 | 0.81 | TP53 (0.48) | ALDH1A1KDM4EL3MBTL1NAMPT | |
| SCHEMBL5323146 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EKMT2ATSHR | |
| SCHEMBL3210271 | 0.79 | L3MBTL1 (0.44) | L3MBTL1ADRB2NAMPT | |
| SCHEMBL5351178 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EKMT2ATSHR | |
| SCHEMBL5369578 | 0.75 | HSD11B1 (0.49) | ALDH1A1MAPTKDM4EKMT2ATSHR | |
| SCHEMBL5321672 | 0.75 | MAPK1 (0.47) | SMN1; SMN2NAMPTMAPK1 | |
| SCHEMBL5322483 | 0.75 | NAMPT (0.43) | KMT2AL3MBTL1NAMPT | |
| SCHEMBL16707807 | 0.75 | L3MBTL1 (0.41) | ALDH1A1MAPTKDM4ETSHRL3MBTL1 | |
| SCHEMBL5359415 | 0.74 | HPGD (0.56) | ALDH1A1MAPTKDM4ETSHRNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135427-A1 | 1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |