Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 4/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 9/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | STS | P08842 | 4/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SNCA | P37840 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11671492 | 0.83 | LMNA (0.42) | HSD17B1ESR1HSD17B10LMNASTS | |
| SCHEMBL978478 | 0.82 | SHBG (0.36) | SHBGSTSHTR2BNR3C1ALDH1A1 | |
| SCHEMBL5680078 | 0.81 | ESR1 (0.38) | SHBGHSD17B1ESR1ESR2HSD17B10 | |
| SCHEMBL6272318 | 0.79 | HSD17B1 (0.44) | SHBGHSD17B1ESR1HSD17B10LMNA | |
| SCHEMBL13714924 | 0.78 | ESR1 (0.51) | SHBGESR1ESR2HSD17B10LMNA | |
| SCHEMBL8038320 | 0.78 | ESR1 (0.51) | SHBGESR1ESR2HSD17B10LMNA | |
| SCHEMBL13846258 | 0.78 | ESR1 (0.40) | SHBGHSD17B1ESR1ESR2HSD17B10 | |
| SCHEMBL8376449 | 0.78 | CYP19A1 (0.54) | SHBGHSD17B1ESR1ESR2HSD17B10 | |
| SCHEMBL14496016 | 0.78 | CYP19A1 (0.54) | SHBGHSD17B1ESR1ESR2HSD17B10 | |
| SCHEMBL8081749 | 0.78 | CYP19A1 (0.54) | SHBGHSD17B1ESR1ESR2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069039-A3 | A PROCESS FOR CONVERTING 17 SUBSTITUTED ANDROSTA-1,4,9(11)-TRIENE-3-ONES TO 17 SUBSTITUTED 3-HYDROXYESTRA-1,3,5(10),9(11)-TETRAENES | PFIZER PROD INC (US) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007069039-A3 | A PROCESS FOR CONVERTING 17 SUBSTITUTED ANDROSTA-1,4,9(11)-TRIENE-3-ONES TO 17 SUBSTITUTED 3-HYDROXYESTRA-1,3,5(10),9(11)-TETRAENES | PFIZER PROD INC (US) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007069039-A2 | A PROCESS FOR CONVERTING 17 SUBSTITUTED ANDROSTA-1,4,9(11)-TRIENE-3-ONES TO 17 SUBSTITUTED 3-HYDROXYESTRA-1,3,5(10),9(11)-TETRAENES | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007069039-A2 | A PROCESS FOR CONVERTING 17 SUBSTITUTED ANDROSTA-1,4,9(11)-TRIENE-3-ONES TO 17 SUBSTITUTED 3-HYDROXYESTRA-1,3,5(10),9(11)-TETRAENES | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| EP-0375347-A1 | Sulphonic acid substituted aromatic steroids as inhibitors of steroid 5-alpha-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0375344-A1 | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0375345-A1 | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |