Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.66 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.66 |
| ▸ | SNCA | P37840 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 3/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330736 | 0.85 | ALDH1A1 (0.64) | KEAP1NFE2L2SNCAMAPTALDH1A1 | |
| SCHEMBL11655582 | 0.83 | SNCA (0.60) | KEAP1NFE2L2SNCAALDH1A1NAMPT | |
| SCHEMBL21761420 | 0.83 | ALDH1A1 (0.69) | KEAP1MAPTALDH1A1GAAALOX15 | |
| SCHEMBL25315174 | 0.81 | MAPT (0.80) | MAPTALDH1A1GAAALOX15TSHR | |
| SCHEMBL5015931 | 0.80 | KEAP1 (0.68) | KEAP1NFE2L2SNCAALDH1A1GAA | |
| SCHEMBL25248383 | 0.80 | ALDH1A1 (0.56) | KEAP1NFE2L2MAPTALPLALDH1A1 | |
| SCHEMBL4814251 | 0.79 | HDAC3 (0.73) | — | |
| SCHEMBL2565637 | 0.78 | KEAP1 (0.64) | KEAP1NFE2L2SNCAALDH1A1GAA | |
| SCHEMBL784141 | 0.78 | KEAP1 (0.66) | KEAP1NFE2L2SNCAALDH1A1GAA | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL4057888 | 0.77 | IL1RN (0.65) | KEAP1MAPTALDH1A1GAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144379-A1 | BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS | MEDIVIR AB (SE) | 2007-12-21 | — | — | WO | disclosed |