Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332046 | 1.00 | POLB (0.58) | POLBTP53ALDH1A1LMNAMAPT | |
| SCHEMBL5331032 | 0.90 | POLB (0.62) | POLBALDH1A1NPSR1HTTKDM4E | |
| SCHEMBL5331037 | 0.90 | POLB (0.62) | POLBALDH1A1NPSR1HTTKDM4E | |
| SCHEMBL5330386 | 0.88 | TP53 (0.67) | POLBTP53ALDH1A1LMNAMAPT | |
| SCHEMBL5330392 | 0.88 | TP53 (0.67) | POLBTP53ALDH1A1LMNAMAPT | |
| SCHEMBL14542416 | 0.87 | TP53 (0.69) | POLBTP53ALDH1A1LMNAMAPT | |
| SCHEMBL5333044 | 0.84 | ALDH1A1 (0.58) | POLBTP53ALDH1A1LMNAMAPT | |
| SCHEMBL5333050 | 0.84 | ALDH1A1 (0.58) | POLBTP53ALDH1A1LMNAMAPT | |
| SCHEMBL5332252 | 0.84 | POLB (0.68) | POLBALDH1A1NPSR1HTTKDM4E | |
| SCHEMBL14542263 | 0.79 | ALDH1A1 (0.69) | POLBTP53ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |