Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10107524 | 0.76 | NPC1 (0.42) | ESR1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL10107525 | 0.75 | PDE4A (0.51) | ESR1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL28748738 | 0.73 | THRA (0.65) | ESR1THRATHRBLMNAMAPT | |
| SCHEMBL5333051 | 0.73 | ESR1 (0.50) | ESR1THRATHRBSMN1; SMN2LMNA | |
| SCHEMBL8595772 | 0.73 | LMNA (0.50) | THRATHRBSMN1; SMN2LMNAMAPT | |
| SCHEMBL2313353 | 0.72 | THRA (0.67) | ESR1THRATHRBLMNAMAPT | |
| SCHEMBL6870341 | 0.72 | AKR1C3 (0.56) | ESR1THRATHRBPLA2G4BAKR1C3 | |
| SCHEMBL27795167 | 0.72 | SMN1; SMN2 (0.52) | THRATHRBSMN1; SMN2LMNAMAPT | |
| SCHEMBL26651124 | 0.72 | HTT (0.53) | ESR1THRATHRBLMNAMAPT | |
| SCHEMBL8596253 | 0.69 | CYP19A1 (0.40) | THRATHRBSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | DEWDNEY NOLAN J | 2007-06-14 | — | — | US | disclosed |
| US-7189731-B2 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1620105-B1 | (6-(PHENOXY)-PYRIDO¬3,4-D|PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS | HOFFMANN LA ROCHE (CH) | 2007-01-10 | — | — | EP | disclosed |
| EP-1620105-A1 | (6-(PHENOXY)-PYRIDO[3,4-D]PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004091625-A1 | (6-(PHENOXY)-PYRIDO`3,4-D! PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORYY CONDITIONS SUCH AS RHEUMATOIS ARTRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-28 | — | — | WO | disclosed |
| US-20040209903-A1 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | MAPK7, MAPK1, MAPK8 | ESR1 3701/4885THRA 2713/4885THRB 2160/4885 |
| US-20040209903-A1 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | MAPK1, MAPK7, MAPK6 | ESR1 4096/4885THRA 3324/4885THRB 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.