Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 9/20 | 0.78 |
| ▸ | CDK4 | P11802 | 3/20 | 0.78 |
| ▸ | CCND1 | P24385 | 3/20 | 0.78 |
| ▸ | CDK2 | P24941 | 3/20 | 0.78 |
| ▸ | PRKCA | P17252 | 2/20 | 0.78 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.78 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.78 |
| ▸ | PRKACA | P17612 | 2/20 | 0.78 |
| ▸ | PRKACG | P22612 | 2/20 | 0.78 |
| ▸ | PRKACB | P22694 | 2/20 | 0.78 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.78 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.78 |
| ▸ | ABL1 | P00519 | 2/20 | 0.78 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.78 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.78 |
| ▸ | PRKCG | P05129 | 1/20 | 0.78 |
| ▸ | CDK1 | P06493 | 1/20 | 0.78 |
| ▸ | PIM1 | P11309 | 1/20 | 0.78 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.78 |
| ▸ | PRKCH | P24723 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756414 | 1.00 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA | |
| Ro-316233 SCHEMBL29373011 | 0.88 | PRKCB (1.00) | PRKCBCDK4CCND1CDK2PRKCA | |
| Ro-316233 SCHEMBL624896 | 0.88 | PRKCB (1.00) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL7822950 | 0.82 | PRKCB (0.74) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL9085566 | 0.82 | CDK4 (0.74) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL9086205 | 0.81 | PRKCB (0.72) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL9085668 | 0.81 | PRKCB (0.72) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL3148490 | 0.81 | PRKCB (0.84) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL3908534 | 0.81 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA | |
| SCHEMBL13917970 | 0.81 | PRKCB (0.78) | PRKCBCDK4CCND1CDK2PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004083202-A1 | A PROCESS FOR THE PREPARATION OF INDOLYMALEIMIDES | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-09-30 | — | — | WO | claimed |
| EP-3805214-B1 | JAK3 SELECTIVE INHIBITOR | UNIV PEKING SHENZHEN GRADUATE SCHOOL (CN) | 2023-07-05 | — | — | EP | disclosed |
| EP-3805214-A1 | JAK3 SELECTIVE INHIBITOR | Peking University Shenzhen Graduate School (CN) | 2021-04-14 | — | — | EP | disclosed |
| WO-2019228442-A1 | JAK3 SELECTIVE INHIBITOR | 北京大学深圳研究生院 (CN) | 2019-12-05 | — | — | WO | disclosed |
| US-7202255-B2 | Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-04-10 | — | — | US | disclosed |
| EP-1587810-B1 | NOVEL SUBSTITUTED 1,4|BENZODIOXINO 2,3-E|ISOINDOLE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2006-11-08 | — | — | EP | disclosed |
| US-20060040930-A1 | Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-02-23 | — | — | US | disclosed |
| WO-2004083202-A1 | A PROCESS FOR THE PREPARATION OF INDOLYMALEIMIDES | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-09-30 | — | — | WO | disclosed |
| EP-0397060-B1 | Maleinimide derivatives and their use as medicines | GOEDECKE AG (DE) | 2001-11-21 | — | — | EP | disclosed |
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| US-5516915-A | Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| US-5380746-A | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1995-01-10 | — | — | US | disclosed |
| EP-0328026-B1 | SUBSTITUTED PYRROLES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0397060-A2 | Maleinimide derivatives and their use as medicines | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040930-A1 | Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | CYP11B2, CYP2F1, CYP3A43 | PRKCB 3888/4885CDK4 1647/4885CCND1 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.