Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395256 | 1.00 | SIGMAR1 (0.42) | SIGMAR1GSK3AGSK3BCHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL5740537 | 0.98 | SIGMAR1 (0.41) | SIGMAR1GSK3AGSK3BCHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL28871686 | 0.86 | KDM1A (0.36) | SIGMAR1 | |
| SCHEMBL2007099 | 0.84 | SIGMAR1 (0.42) | SIGMAR1GSK3AGSK3BCHRNB2CHRNA4 | |
| SCHEMBL19447878 | 0.76 | CYP11B2 (0.46) | SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2 | |
| SCHEMBL27269792 | 0.72 | GSK3A (0.43) | GSK3AGSK3B | |
| SCHEMBL30130240 | 0.71 | SIGMAR1 (0.36) | SIGMAR1CHRNB2CHRNA4PDE3BPDE3A | |
| SCHEMBL29421729 | 0.70 | GSK3A (0.46) | GSK3AGSK3BBCHEMAOAMAOB | |
| SCHEMBL461295 | 0.70 | GSK3A (0.46) | GSK3AGSK3BBCHEMAOAMAOB | |
| SCHEMBL13859951 | 0.69 | CYP11B1 (0.37) | SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481826-A1 | TYROSINE KINASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2019-05-15 | — | — | EP | claimed |
| WO-2018009938-A1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2018-01-11 | — | — | WO | claimed |
| WO-2016183071-A1 | HETERO-TRICYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2016-11-17 | — | — | WO | claimed |
| EP-1667982-B1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2013-07-31 | — | — | EP | claimed |
| WO-2007053353-A2 | PYRROLO[2,3-F] AND [3,2-F]ISOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | claimed |
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | claimed |
| US-11672791-B2 | Tyrosine kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20230012676-A1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-01-19 | — | — | US | disclosed |
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-115087486-A | Substituted bicyclic and tricyclic ureas and amides, analogs thereof, and methods of use thereof | 爱彼特生物制药公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-112979644-B | Method for preparing fluoromethylation indole [2,1, a ] isoquinoline derivative by using photocatalysis microchannel | 南京工业大学 | 2021-11-30 | — | — | CN | disclosed |
| EP-3481826-B1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3887478-A1 | COMPOUNDS FOR ELECTRONIC DEVICES | Merck Patent GmbH (DE) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020085234-A1 | MORPHINAN DERIVATIVE | 日本ケミファ株式会社 | 2020-04-30 | — | — | WO | disclosed |
| EP-3481826-A1 | TYROSINE KINASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2019-05-15 | — | — | EP | disclosed |
| WO-2018009938-A1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2018-01-11 | — | — | WO | disclosed |
| WO-2016183071-A1 | HETERO-TRICYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2007053353-A2 | PYRROLO[2,3-F] AND [3,2-F]ISOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| EP-0958285-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030546-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230012676-A1 | TYROSINE KINASE INHIBITORS | TYRO3, AXL, RET | SIGMAR1 874/4885GSK3A 1137/4885GSK3B 1024/4885 |
| US-11672791-B2 | Tyrosine kinase inhibitors | TYRO3, AXL, RET | SIGMAR1 874/4885GSK3A 1137/4885GSK3B 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.