SCHEMBL5333503

SCHEMBL5333503

CNC(=O)c1cc2c(CO[C@H](C)c3ccccc3)c[nH]c2cn1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.47
NPC1 O15118 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
TP53 P04637 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
MAPT P10636 1/20 0.47
CYP2C9 P11712 1/20 0.47
PKM P14618 1/20 0.47
HPGD P15428 1/20 0.47
TSHR P16473 1/20 0.47
APEX1 P27695 1/20 0.47
CYP2C19 P33261 1/20 0.47
THPO P40225 1/20 0.47
RAB9A P51151 1/20 0.47
PMP22 Q01453 1/20 0.47
HSD17B10 Q99714 1/20 0.47
GABRA1 P14867 1/20 0.44
GABRG2 P18507 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9083240 0.70 GABRA1 (0.52) KDM4ENPC1ALDH1A1LMNACYP1A2
SCHEMBL9386471 0.69 KMT2A (0.47) KDM4EALDH1A1MAPTHPGDGABRA1
SCHEMBL30232368 0.65 ALDH1A1 (1.00) KDM4ENPC1ALDH1A1LMNATP53
SCHEMBL194445 0.65 ALDH1A1 (1.00) KDM4ENPC1ALDH1A1LMNATP53
SCHEMBL29425001 0.65 ALDH1A1 (1.00) KDM4ENPC1ALDH1A1LMNATP53
SCHEMBL2953007 0.65 GABRA1 (0.56) KDM4ENPC1ALDH1A1LMNACYP1A2
SCHEMBL2945211 0.64 GABRA1 (0.60) KDM4ENPC1ALDH1A1LMNACYP1A2
SCHEMBL5251138 0.63 KDM4E (0.38) KDM4ENPC1ALDH1A1LMNATP53
SCHEMBL30753126 0.63 MEN1 (0.49) ALDH1A1MEN1KMT2A
SCHEMBL2951128 0.62 GABRA1 (0.57) KDM4ENPC1ALDH1A1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1756103-A2 PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS HIV-INTEGRASE INHIBITORS Pfizer, Inc. (US) 2007-02-28 EP disclosed
WO-2005103003-A2 PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS HIV-INTEGRASE INHIBITORS PFIZER INC. (US) 2005-11-03 WO disclosed