Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.37 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314023 | 0.92 | KDR (0.47) | KDRLCKEGFRCHEK1SIK2 | |
| SCHEMBL5313556 | 0.91 | MERTK (0.38) | KDRLCKGRM2 | |
| SCHEMBL5312577 | 0.89 | KDR (0.49) | KDRLCKEGFRCHEK1TNIK | |
| SCHEMBL5310432 | 0.85 | KDR (0.49) | KDRLCKEGFRCHEK1SIK2 | |
| SCHEMBL5334782 | 0.83 | MERTK (0.43) | KDR | |
| SCHEMBL5315261 | 0.81 | BDKRB1 (0.37) | KDREGFRJAK2JAK1TYK2 | |
| SCHEMBL5329735 | 0.80 | TNIK (0.41) | KDRLCKTNIK | |
| SCHEMBL5333804 | 0.77 | DRD4 (0.40) | KDR | |
| SCHEMBL5333764 | 0.77 | TNIK (0.41) | KDRTNIKGRM2 | |
| SCHEMBL5312320 | 0.76 | KDR (0.49) | KDRCHEK1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | claimed |