Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.37 |
| ▸ | CCND3 | P30281 | 3/20 | 0.37 |
| ▸ | CCND1 | P24385 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311867 | 0.91 | MERTK (0.45) | CDK6CCND3CDK4MERTKMET | |
| SCHEMBL5313507 | 0.90 | DYRK2 (0.45) | CDK6CCND3CCND1CDK4MERTK | |
| SCHEMBL5315552 | 0.90 | BDKRB1 (0.40) | BDKRB1CDK6CCND3CCND1CDK4 | |
| SCHEMBL5314023 | 0.89 | KDR (0.47) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL5314922 | 0.87 | PDE1B (0.35) | CDK6CCND3CCND1CDK4MERTK | |
| SCHEMBL5336063 | 0.85 | GRM2 (0.37) | CDK6CCND3CCND1CDK4MERTK | |
| SCHEMBL5315878 | 0.83 | ABL1 (0.46) | EGFRCCNT1 | |
| SCHEMBL5311883 | 0.81 | TNIK (0.45) | CDK6CCND3CDK4MERTKKDR | |
| SCHEMBL5333643 | 0.81 | KDR (0.46) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL5334782 | 0.80 | MERTK (0.43) | MERTKMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | disclosed |