Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | FADS1 | O60427 | 1/20 | 0.55 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369046 | 0.80 | EGFR (0.60) | EGFRFADS1PIP4K2CFLT1AURKA | |
| SCHEMBL24466918 | 0.80 | EGFR (0.64) | EGFRFADS1PIP4K2CALDH1A1GAA | |
| SCHEMBL29808690 | 0.80 | EGFR (0.64) | EGFRFADS1PIP4K2CALDH1A1GAA | |
| SCHEMBL13434856 | 0.79 | FADS1 (0.59) | EGFRFADS1PIP4K2CFLT1CSNK2A1 | |
| SCHEMBL5455935 | 0.79 | EGFR (0.62) | EGFRFADS1PIP4K2CFLT1AURKA | |
| SCHEMBL29808582 | 0.78 | PIP4K2C (0.61) | EGFRFADS1PIP4K2CFLT1CSNK2A1 | |
| SCHEMBL13434848 | 0.78 | PIP4K2C (0.61) | EGFRFADS1PIP4K2CFLT1CSNK2A1 | |
| SCHEMBL30715841 | 0.78 | EGFR (0.69) | EGFRFADS1PIP4K2CFLT1CSNK2A1 | |
| SCHEMBL5331005 | 0.77 | CSNK2A1 (0.58) | EGFRFADS1PIP4K2CCSNK2A1 | |
| SCHEMBL13434857 | 0.75 | PIP4K2C (0.54) | EGFRFADS1PIP4K2CFLT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056215-A9 | N-ARYL-THIENOPYRIMIDIN-4-AMINES AND THE USE THEREOF | CYTOVIA INC (US) | 2007-09-13 | — | — | WO | claimed |
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-05-03 | — | — | US | claimed |
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099877-A1 | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP4, CASP3, API5 | EGFR 1226/4885FADS1 1782/4885PIP4K2C 2195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.