Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290092 | 1.00 | HTT (0.56) | HTTALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL13806337 | 0.82 | HTT (0.54) | HTTALDH1A1L3MBTL1TP53MEN1 | |
| SCHEMBL11828840 | 0.82 | HTT (0.68) | HTTALDH1A1L3MBTL1TP53MEN1 | |
| SCHEMBL7806227 | 0.80 | MAPK1 (0.53) | HTTALDH1A1L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL7802853 | 0.80 | MAPK1 (0.53) | HTTALDH1A1L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL6050299 | 0.79 | HTT (0.51) | HTTALDH1A1L3MBTL1TP53MEN1 | |
| SCHEMBL5309816 | 0.78 | ALDH1A1 (0.53) | HTTALDH1A1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL7804032 | 0.77 | ATM (0.46) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7802034 | 0.77 | ATM (0.46) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10869246 | 0.76 | ALDH1A1 (0.50) | HTTALDH1A1SMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436449-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | Merck Patent GmbH (DE) | 2019-02-06 | — | — | EP | disclosed |
| US-9975902-B2 | Compounds for the inhibition of cyclophilins and uses thereof | MERCK PATENT GMBH (DE) | 2018-05-22 | — | — | US | disclosed |
| US-20170283427-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-10-05 | — | — | US | disclosed |
| WO-2017173052-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-10-05 | — | — | WO | disclosed |
| WO-2007029156-A2 | ISOINDOLEDIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | disclosed |
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |
| US-4017299-A | Phthalimide derivatives as plant growth regulants | AMERICAN CYANAMID COMPANY (US) | 1977-04-12 | — | — | US | disclosed |
| US-3968217-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-07-06 | — | — | US | disclosed |
| US-3940419-A | Phthalimide derivatives and their use as plant growth regulants | AMERICAN CYANAMID COMPANY (US) | 1976-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283427-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | PPIG, PPIH, FKBP2 | HTT 236/4885ALDH1A1 1226/4885L3MBTL1 2665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.