Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10427641 | 0.82 | ADRA1A (0.43) | ADRA1AADRA1BADRA1DALOX5APFEN1 | |
| SCHEMBL30102602 | 0.82 | ADRA1A (0.43) | ADRA1AADRA1BADRA1DALOX5APFEN1 | |
| SCHEMBL29669833 | 0.82 | ADRA1A (0.43) | ADRA1AADRA1BADRA1DALOX5APFEN1 | |
| SCHEMBL946697 | 0.79 | KDM4E (0.50) | ADRA1AADRA1BADRA1DCYP2A6ALDH1A1 | |
| SCHEMBL12853973 | 0.78 | ALOX5AP (0.50) | ADRA1AADRA1BADRA1DALOX5APFEN1 | |
| SCHEMBL12853984 | 0.78 | ALOX5AP (0.50) | ADRA1AADRA1BADRA1DALOX5APFEN1 | |
| SCHEMBL11795254 | 0.73 | CYP2A6 (0.50) | CYP2A6ALDH1A1ALOX15MAPTKDM4E | |
| SCHEMBL2556892 | 0.72 | DCTPP1 (0.54) | ADRA1AADRA1BADRA1DALOX5APFEN1 | |
| SCHEMBL4073407 | 0.72 | ADRA1A (0.43) | ADRA1AADRA1BADRA1DALOX5APFEN1 | |
| SCHEMBL3948877 | 0.72 | IDO1 (0.48) | ADRA1AADRA1BADRA1DALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007515442-A | — | — | 2007-06-14 | — | — | JP | claimed |
| US-7183280-B2 | Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-27 | — | — | US | claimed |
| EP-1709049-A1 | BICYCLIC IMIDAZOLE COMPOUNDS, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2006-10-11 | — | — | EP | claimed |
| WO-2005063750-A1 | BICYCLIC IMIDAZOLE COMPOUNDS, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-14 | — | — | WO | claimed |
| US-20050143377-A1 | Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-30 | — | — | US | claimed |
| US-7183280-B2 | Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| EP-1709049-A1 | BICYCLIC IMIDAZOLE COMPOUNDS, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005063750-A1 | BICYCLIC IMIDAZOLE COMPOUNDS, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |
| US-20050143377-A1 | Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143377-A1 | Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions | DPP4, DPP3, DPP7 | ADRA1A 1129/4885ADRA1B 904/4885ADRA1D 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.