Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28170355 | 0.85 | P2RX7 (0.51) | IDO1NPY5RGRM5PIEZO1P2RX7 | |
| SCHEMBL12853984 | 0.83 | ALOX5AP (0.50) | HSD17B10CYP19A1HPGDCYP1A2ADRA1A | |
| SCHEMBL12853973 | 0.83 | ALOX5AP (0.50) | HSD17B10CYP19A1HPGDCYP1A2ADRA1A | |
| SCHEMBL6662455 | 0.82 | ALOX5AP (0.42) | NPY5RHSD17B10HPGDNPC1RAB9A | |
| SCHEMBL29157047 | 0.79 | CNR1 (0.40) | NPY5RHSD17B10CYP19A1HPGDNPC1 | |
| SCHEMBL7486893 | 0.78 | PIEZO1 (0.47) | HSD17B10CYP19A1NPC1RAB9AADRA1A | |
| SCHEMBL30767271 | 0.77 | IDO1 (0.50) | IDO1NPY5RNPC1RAB9AKMT2A | |
| SCHEMBL6074928 | 0.77 | RAB9A (0.48) | NPC1RAB9AL3MBTL1GRM5SMN1; SMN2 | |
| SCHEMBL532788 | 0.77 | MAPT (0.51) | HSD17B10HPGDNPC1RAB9AADRA1A | |
| SCHEMBL3948151 | 0.77 | IDO1 (0.50) | IDO1NPY5RNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867374-A | Mildew preventive, mildew-proof product and mildew-proof paint | 共同印刷株式会社 | 2023-10-10 | — | — | CN | disclosed |
| CN-106397406-B | A kind of heteroaromatic derivative and preparation method thereof and a kind of organic electroluminescence device | 吉林奥来德光电材料股份有限公司 | 2019-06-18 | — | — | CN | disclosed |
| EP-3495359-A1 | FLAP MODULATORS | Janssen Pharmaceutica NV (BE) | 2019-06-12 | — | — | EP | disclosed |
| EP-3070085-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | disclosed |
| EP-2951170-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-10-24 | — | — | EP | disclosed |
| CN-105085516-B | Aromatic heterocyclic derivative, preparation method thereof and organic electroluminescent device | 吉林奥来德光电材料股份有限公司 | 2018-07-10 | — | — | CN | disclosed |
| US-9884878-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-06 | — | — | US | disclosed |
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| CN-106397406-A | Aromatic heterocyclic derivative and preparing method thereof and inorganic electroluminescence device | 吉林奥来德光电材料股份有限公司 | 2017-02-15 | — | — | CN | disclosed |
| EP-3070085-A1 | FLAP MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2016-09-21 | — | — | EP | disclosed |
| CN-102325767-A | 7-phenoxy chroman carboxylic acid derivative | ARRAY BIOPHARMA INC | 2012-01-18 | — | — | CN | disclosed |
| CN-1930162-B | Tetrahydropyridoindole derivatives | ACTELION PHARMACEUTICALS LTD | 2010-06-16 | — | — | CN | disclosed |
| CN-101679235-A | Azetidine derivatives and their use as prostaglandin E2 antagonists | PFIZER LTD | 2010-03-24 | — | — | CN | disclosed |
| CN-101541792-A | Azaadamantane derivatives and methods of use | ABBOTT LAB (US) | 2009-09-23 | — | — | CN | disclosed |
| US-7572797-B2 | Amino substituted pyrazine derivatives for the treatment of pain | PFIZER INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-20070105872-A1 | N-[6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl]-3-methylisoxazole-4-carboxamide; N-[6-amino-5-(2,3-dichloro-5-methoxyphenyl)pyrazin-2-yl]-1-methyl-1H-pyrazole-5-carboxamide | PFIZER LIMITED | 2007-05-10 | — | — | US | disclosed |
| CN-1930162-A | Tetrahydropyridoindole derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-14 | — | — | CN | disclosed |
| EP-0204172-B1 | PHENYLPYRAZINE DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1990-09-19 | — | — | EP | disclosed |
| US-4755514-A | Phenylpyrazine derivatives and thrombolytic agent | SUNTORY LIMITED (JP) | 1988-07-05 | — | — | US | disclosed |
| EP-0204172-A2 | Phenylpyrazine derivatives, processes for preparing them, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1986-12-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105872-A1 | N-[6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl]-3-methylisoxazole-4-carboxamide; N-[6-amino-5-(2,3-dichloro-5-methoxyphenyl)pyrazin-2-yl]-1-methyl-1H-pyrazole-5-carboxamide | P2RX5, P2RX3, AADAC | IDO1 1481/4885NPY5R 64/4885HSD17B10 3235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.