Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 5/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | METAP2 | P50579 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118472 | 0.74 | DYRK1A (0.39) | DYRK1AHSP90AA1IDO1CDK2NOS1 | |
| SCHEMBL23530790 | 0.74 | ALDH1A1 (0.44) | DYRK1AHSP90AA1IDO1CDK2NOS1 | |
| SCHEMBL3117779 | 0.74 | DYRK1A (0.39) | DYRK1AHSP90AA1IDO1CDK2NOS1 | |
| SCHEMBL3120925 | 0.71 | DYRK1A (0.34) | DYRK1AHSP90AA1IDO1CDK2MKNK1 | |
| SCHEMBL3120521 | 0.69 | DYRK1A (0.36) | DYRK1AHSP90AA1IDO1CDK2CHEK1 | |
| SCHEMBL3105087 | 0.69 | DYRK1A (0.36) | DYRK1AHSP90AA1IDO1CDK2CHEK1 | |
| SCHEMBL2331764 | 0.69 | DYRK1A (0.36) | DYRK1AHSP90AA1IDO1CDK2CHEK1 | |
| SCHEMBL31382890 | 0.69 | METAP2 (0.41) | DYRK1AHSP90AA1IDO1CDK2CHEK1 | |
| SCHEMBL22941856 | 0.69 | DYRK1A (0.36) | DYRK1AHSP90AA1IDO1CDK2CHEK1 | |
| SCHEMBL6886742 | 0.68 | XDH (0.34) | DYRK1AHSP90AA1IDO1CDK2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378483-B1 | Use of 4-mercapto-6-hydroxy-pyrazolo-(4,3-d)-pyrimidine as a scavenger of free radicals | BOUCHARA SA (FR) | 1996-08-14 | — | — | EP | claimed |
| WO-2007069924-A1 | DEAZAPURINE ANALOGS OF 4'-AZA-L-NUCLEOSIDES | INDUSTRIAL RESEARCH LIMITED (NZ) | 2007-06-21 | — | — | WO | disclosed |