Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | C1R | P00736 | 5/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | C1S | P09871 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892212 | 0.79 | ALDH1A1 (0.41) | MEN1POLBKMT2AC1RALDH1A1 | |
| SCHEMBL8011185 | 0.79 | ALDH1A1 (0.46) | MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL2230905 | 0.77 | MAPT (0.48) | MEN1POLBKMT2AALDH1A1ALOX15 | |
| SCHEMBL11052520 | 0.74 | POLB (0.40) | MEN1POLBKMT2AALDH1A1ALOX15 | |
| SCHEMBL9617399 | 0.74 | MEN1 (0.40) | MEN1POLBKMT2AALDH1A1ALOX15 | |
| SCHEMBL852350 | 0.74 | EDNRB (0.33) | MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL7248118 | 0.73 | RAB9A (0.46) | MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL2182063 | 0.73 | KMT2A (0.46) | MEN1POLBKMT2AALDH1A1ALOX15 | |
| SCHEMBL8554351 | 0.73 | ALDH1A1 (0.43) | MEN1POLBKMT2AALDH1A1ALOX15 | |
| SCHEMBL7884961 | 0.73 | MAOB (0.40) | MEN1POLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006032518-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | disclosed |