Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17434732 | 1.00 | MAPT (0.44) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL533849 | 1.00 | MAPT (0.44) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL28407169 | 0.98 | MAPT (0.43) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL5774843 | 0.84 | MAPT (0.43) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL5774846 | 0.84 | MAPT (0.43) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL1931859 | 0.79 | GRIN2D (0.61) | MAPTRAB9AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL29775672 | 0.79 | GRIN2D (0.61) | MAPTRAB9AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL2928249 | 0.79 | GRIN2D (0.61) | MAPTRAB9AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL1931856 | 0.79 | GRIN2D (0.61) | MAPTRAB9AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL4049047 | 0.79 | MAPT (0.59) | MAPTCYP1A2CYP2C19L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4592287-A1 | 2H-BENZOTRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Orxes Therapeutics Co., Ltd. (CN) | 2025-07-30 | — | — | EP | disclosed |
| CN-115304590-B | 2H-benzotriazole derivatives, preparation method thereof and pharmaceutical composition containing same | 皮摩尔新药(辽宁)有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-115381827-B | Application of benzotriazole derivative in preparation of medicine for treating or preventing cardiovascular diseases | 皮摩尔新药(辽宁)有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-110845486-B | Triazole alcohol derivative and preparation method and application thereof | 中国人民解放军第二军医大学 | 2023-03-21 | — | — | CN | disclosed |
| CN-115381827-A | Application of benzotriazole alkyl derivative in preparation of medicine for treating or preventing cardiovascular diseases | 皮摩尔新药(辽宁)有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115304590-A | 2H-benzotriazole derivatives, preparation method thereof and pharmaceutical composition containing same | 皮摩尔新药(辽宁)有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-110845486-A | Triazole alcohol derivative and preparation method and application thereof | 中国人民解放军第二军医大学 | 2020-02-28 | — | — | CN | disclosed |
| US-9580444-B2 | Polycyclic pyrazolinone derivative and herbicide comprising same as effective component thereof | SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) | 2017-02-28 | — | — | US | disclosed |
| US-9580444-B2 | Polycyclic pyrazolinone derivative and herbicide comprising same as effective component thereof | SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) | 2017-02-28 | — | — | US | disclosed |
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
| WO-2014142307-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | 公益財団法人相模中央化学研究所 (JP) | 2014-09-18 | — | — | WO | disclosed |
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |
| WO-2006064484-A1 | AZABICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | DDT, PDHX, CYP4X1 | MAPT 4308/4885NPC1 4857/4885RAB9A 3766/4885 |
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MAPT 4208/4885NPC1 1715/4885RAB9A 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.