Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 7/20 | 1.00 |
| ▸ | KCNQ2 | O43526 | 7/20 | 1.00 |
| ▸ | KCNQ5 | Q9NR82 | 6/20 | 1.00 |
| ▸ | KCNE1 | P15382 | 5/20 | 1.00 |
| ▸ | KCNQ1 | P51787 | 5/20 | 1.00 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.63 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | GRM5 | P41594 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086307 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5346150 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516639 | 0.83 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL23406057 | 0.83 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL29743886 | 0.83 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL3675463 | 0.82 | KCNK3 (0.84) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL5338598 | 0.81 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL3786882 | 0.80 | KCNK3 (0.87) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL14516646 | 0.80 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 | |
| SCHEMBL3674558 | 0.80 | KCNK3 (0.71) | KCNQ3KCNQ2KCNQ5KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| EP-1483259-A4 | PYRIMIDINES AS NOVEL OPENERS OF POTASSIUM ION CHANNELS | ICAGEN INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1483259-A1 | PYRIMIDINES AS NOVEL OPENERS OF POTASSIUM ION CHANNELS | Icagen, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20030181465-A1 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. | 2003-09-25 | — | — | US | disclosed |
| WO-2003068767-A1 | PYRIMIDINES AS NOVEL OPENERS OF POTASSIUM ION CHANNELS | ICAGEN, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181465-A1 | Pyrimidines as novel openers of potassium ion channels | KCNJ1, KCNJ2, KCNJ11 | KCNQ3 22/4885KCNQ2 12/4885KCNQ5 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.