Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534760 | 0.86 | REN (0.60) | RENKCNH2CYP3A4 | |
| SCHEMBL556192 | 0.80 | ABCB1 (0.39) | RENKCNH2L3MBTL1CD274ENPP2 | |
| SCHEMBL10202500 | 0.80 | REN (0.56) | RENKCNH2L3MBTL1CYP3A4ENPP2 | |
| SCHEMBL556382 | 0.76 | REN (0.39) | RENKCNH2L3MBTL1IDO1CD274 | |
| SCHEMBL7863795 | 0.73 | REN (0.54) | RENKCNH2CYP3A4 | |
| SCHEMBL533903 | 0.70 | REN (0.46) | RENKCNH2CD274CYP3A4 | |
| SCHEMBL7863764 | 0.69 | REN (0.58) | RENKCNH2CYP3A4 | |
| SCHEMBL10202506 | 0.68 | REN (0.63) | RENKCNH2CYP3A4 | |
| SCHEMBL7872527 | 0.68 | REN (0.61) | RENKCNH2CYP3A4 | |
| SCHEMBL7870969 | 0.67 | REN (0.49) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |