Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533911 | 0.86 | REN (0.48) | RENKCNH2CYP3A4 | |
| SCHEMBL7863764 | 0.82 | REN (0.58) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL7872527 | 0.81 | REN (0.61) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL533903 | 0.80 | REN (0.46) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL10202485 | 0.77 | REN (0.69) | RENKCNH2CYP3A4 | |
| SCHEMBL10202479 | 0.77 | REN (0.69) | RENKCNH2CYP3A4 | |
| SCHEMBL557035 | 0.76 | REN (0.43) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL7873280 | 0.75 | REN (0.85) | RENKCNH2CYP3A4 | |
| SCHEMBL10202561 | 0.75 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL7871265 | 0.75 | REN (0.85) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |