Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534448 | 0.84 | REN (0.48) | RENKCNH2CYP3A4L3MBTL1 | |
| SCHEMBL535511 | 0.78 | REN (0.66) | RENKCNH2CYP3A4PTGDR2 | |
| SCHEMBL534056 | 0.78 | REN (0.39) | RENKCNH2CYP3A4CHRM3DPP4 | |
| SCHEMBL533878 | 0.74 | REN (0.54) | RENKCNH2CYP3A4 | |
| SCHEMBL556870 | 0.71 | REN (0.75) | RENKCNH2CYP3A4CHRM3MAPT | |
| SCHEMBL557570 | 0.69 | REN (0.43) | RENKCNH2CHRM3CHRM5CHRM2 | |
| SCHEMBL534449 | 0.67 | REN (0.66) | RENKCNH2CYP3A4CHRM3PTGDR2 | |
| SCHEMBL535144 | 0.66 | REN (0.74) | RENKCNH2CYP3A4MAPTLMNA | |
| SCHEMBL7862530 | 0.66 | REN (0.63) | RENKCNH2CYP3A4CHRM3CHRM1 | |
| SCHEMBL10202578 | 0.65 | REN (1.00) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |