Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31636947 | 0.83 | TACR1 (0.45) | TACR1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL5342544 | 0.81 | TACR1 (0.52) | TACR1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL7324607 | 0.80 | IDO1 (0.43) | TACR1AGTR1PTGS2LMNAKDM4E | |
| SCHEMBL14463630 | 0.78 | PTGS2 (0.58) | TACR1AGTR1PTGS2KMT2APADI4 | |
| SCHEMBL31636783 | 0.74 | TACR1 (0.43) | TACR1PDE3BPDE3ACCNE1CDK2 | |
| SCHEMBL5470895 | 0.73 | TACR1 (1.00) | TACR1 | |
| SCHEMBL5335958 | 0.73 | TACR1 (0.58) | TACR1AGTR1PTGS2KMT2APADI4 | |
| SCHEMBL4494163 | 0.72 | TACR1 (0.59) | TACR1AGTR1KMT2ALMNAKDM4E | |
| SCHEMBL31636422 | 0.70 | EGLN1 (0.55) | TACR1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL29636632 | 0.70 | MAPK8 (0.41) | TACR1PDE3BPDE3ACCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007074491-A1 | HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007074491-A1 | HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2007-07-05 | — | — | WO | disclosed |