Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PADI4 | Q9UM07 | 4/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14463536 | 0.82 | SMN1; SMN2 (0.54) | TACR1LMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL14463630 | 0.79 | PTGS2 (0.58) | TACR1AGTR1PTGS2LMNAPADI4 | |
| SCHEMBL8597724 | 0.76 | REN (0.41) | TACR1LMNAKMT2AALDH1A1HPGD | |
| SCHEMBL5339664 | 0.73 | TACR1 (0.59) | TACR1AGTR1PTGS2LMNAPADI4 | |
| SCHEMBL3356849 | 0.70 | GABRA5 (0.50) | GABRA5TDO2 | |
| SCHEMBL28322929 | 0.69 | AGTR1 (0.50) | AGTR1PTGS2LMNAPADI4KMT2A | |
| SCHEMBL4494163 | 0.68 | TACR1 (0.59) | TACR1AGTR1LMNAKMT2APOLB | |
| SCHEMBL2490336 | 0.65 | AGTR1 (0.53) | AGTR1LMNAKMT2APOLBKDM4E | |
| SCHEMBL29262209 | 0.65 | LMNA (0.55) | AGTR1LMNAKMT2APOLBKDM4E | |
| SCHEMBL10924110 | 0.64 | GABRA5 (0.55) | GABRA5KDM4EALDH1A1BRD9TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007074491-A1 | HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007074491-A1 | HETEROTRICYCLIC AMIDE DERIVATIVES AS NEUROKININ-l (NKl) RECEPTOR LIGANDS | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2007-07-05 | — | — | WO | disclosed |