Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041829 | 0.92 | CYP3A4 (0.73) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL759012 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL8788785 | 0.86 | ALDH1A1 (0.74) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| Hydrochloric Acid SCHEMBL28469611 | 0.85 | ALDH1A1 (0.97) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL8991913 | 0.84 | ALDH1A1 (0.72) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL7563232 | 0.84 | ALDH1A1 (0.72) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL8992671 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL8991912 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL2361415 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL8765881 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841924-B1 | BENZIMIDAZOLE COMPOUNDS | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-10-02 | — | — | EP | claimed |
| EP-0841924-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-05-20 | — | — | EP | claimed |
| WO-1997004771-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1997-02-13 | — | — | WO | claimed |
| CN-107089972-B | Preparation method of candesartan cilexetil | 浙江华海药业股份有限公司 | 2021-05-18 | — | — | CN | disclosed |
| EP-1778650-A1 | PROCESS FOR PREPARING CANDESARTAN CILEXETIL | Dr. Reddy's Laboratories Ltd. (IN) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015134-A1 | PROCESS FOR PREPARING CANDESARTAN CILEXETIL | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-02-09 | — | — | WO | disclosed |
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |
| EP-0841924-B1 | BENZIMIDAZOLE COMPOUNDS | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-10-02 | — | — | EP | disclosed |
| US-6310082-B1 | PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE POLY(ADP-RIBOSE)POLYMERASE ENZYME INHIBITING AMOUNT OF BENZIMIDAZOLE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PRO-DRUG FORM THEREOF, WITH ACCEPTABLE CARRIER | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-30 | — | — | US | disclosed |
| US-6100283-A | PRODRUG PHOSPHATE DERIVATIVE FOR POLY (ADP-RIBOSE) POLYMERASE ENZYME INHIBITOR FOR ADMINISTERING IN CONJUNCTION WITH ANTITUMOR DRUG OR RADIOTHERAPY | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-08-08 | — | — | US | disclosed |
| EP-0841924-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004771-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1997-02-13 | — | — | WO | disclosed |