Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533862 | 0.86 | REN (0.45) | RENKCNH2KDM1ACHRNB2CHRNA4 | |
| SCHEMBL533861 | 0.86 | REN (0.45) | RENKCNH2KDM1ACHRNB2CHRNA4 | |
| SCHEMBL534503 | 0.76 | REN (0.36) | RENKCNH2CYP3A4 | |
| SCHEMBL534505 | 0.76 | REN (0.36) | RENKCNH2CYP3A4 | |
| SCHEMBL534504 | 0.76 | REN (0.36) | RENKCNH2CYP3A4 | |
| SCHEMBL534498 | 0.74 | SPR (0.43) | RENKCNH2MEN1KMT2AKDM4E | |
| SCHEMBL7869553 | 0.73 | REN (0.71) | RENKCNH2KDM1ACYP2D6CYP3A4 | |
| SCHEMBL556570 | 0.72 | SLC6A4 (0.32) | RENKCNH2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL556569 | 0.72 | SLC6A4 (0.32) | RENKCNH2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL556568 | 0.72 | SLC6A4 (0.32) | RENKCNH2MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |