Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31454562 | 0.81 | TSHR (0.48) | SLC6A3SLC6A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL1673040 | 0.81 | TSHR (0.48) | SLC6A3SLC6A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL1027499 | 0.78 | HSD17B10 (0.57) | SLC6A3TSHRKMT2AHSD17B10GAA | |
| SCHEMBL1340852 | 0.78 | CES2 (0.61) | SLC6A3SLC6A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL5365431 | 0.77 | ABL1 (0.44) | SLC6A3SLC6A4SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2842204 | 0.76 | TSHR (0.57) | TSHRCYP1A2CYP2D6CYP2C19KMT2A | |
| SCHEMBL28829627 | 0.75 | SLC6A3 (0.57) | SLC6A3SLC6A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL31388963 | 0.75 | NR1I2 (0.46) | SLC6A3SLC6A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL1957490 | 0.72 | HTT (0.57) | TSHRCYP1A2CES2BCHECES1 | |
| SCHEMBL13824070 | 0.72 | SLC6A3 (0.53) | SLC6A3SLC6A4TSHRNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784390-A2 | SUBSTITUTED BENZOFUSED HETEROCYCLES | Amgen Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006020959-A2 | SUBSTITUTED BENZOFUSED HETEROCYCLES | AMGEN INC. (US) | 2006-02-23 | — | — | WO | disclosed |