Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534040 | 0.90 | PTGDR2 (0.45) | PTGDR2NR1H3NR1H2PI4KBPDE4A | |
| SCHEMBL534029 | 0.86 | PTGDR2 (0.64) | PTGDR2NR1H3NR1H2PDE4APDE4B | |
| SCHEMBL534097 | 0.84 | PTGDR2 (0.55) | PTGDR2NR1H3NR1H2PI4KBPDE4A | |
| SCHEMBL534795 | 0.79 | PTGDR2 (0.51) | PTGDR2 | |
| SCHEMBL534081 | 0.78 | PTGDR2 (0.49) | PTGDR2PARP1 | |
| SCHEMBL534007 | 0.76 | PTGDR2 (0.50) | PTGDR2DHFR | |
| SCHEMBL3773874 | 0.75 | PTGDR2 (0.70) | PTGDR2 | |
| SCHEMBL533907 | 0.73 | PTGS2 (0.38) | PTGDR2 | |
| SCHEMBL3784679 | 0.71 | PTGDR2 (0.57) | PTGDR2 | |
| SCHEMBL14236239 | 0.71 | PTGDR2 (0.57) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129661-B1 | QUINOLINE DERIVATIVES AS CRTH2 RECEPTOR LIGANDS | PULMAGEN THERAPEUTICS ASTHMA LTD (GB) | 2012-02-08 | — | — | EP | claimed |