SCHEMBL5340454

SCHEMBL5340454

CC(C)(C)Sc1ccc(C(F)(F)F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.46
SLC6A4 P31645 3/20 0.42
ALDH1A1 P00352 2/20 0.40
TSHR P16473 1/20 0.40
KDM4E B2RXH2 2/20 0.39
HSD17B10 Q99714 1/20 0.39
KIF11 P52732 5/20 0.39
HAO1 Q9UJM8 1/20 0.39
SLC6A2 P23975 2/20 0.39
SLC6A3 Q01959 1/20 0.39
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
ORAI1 Q96D31 1/20 0.38
ORAI2 Q96SN7 1/20 0.38
ORAI3 Q9BRQ5 1/20 0.38
TRPV6 Q9H1D0 1/20 0.38
MGLL Q99685 1/20 0.38
FBP1 P09467 1/20 0.38
TRPV1 Q8NER1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7014603 0.80 ALDH1A1 (0.58) ALDH1A1TSHRKDM4EKIF11HAO1
SCHEMBL11333974 0.80 TSHR (0.48) SLC6A4ALDH1A1TSHRKDM4EHSD17B10
SCHEMBL12807846 0.77 TRPV1 (0.43) ARSLC6A4ALDH1A1TSHRKDM4E
SCHEMBL695441 0.75 ALDH1A1 (0.43) SLC6A4ALDH1A1TSHRKDM4EKIF11
SCHEMBL7937564 0.75 SLC6A4 (0.45) ARSLC6A4ALDH1A1KDM4EHSD17B10
SCHEMBL24499138 0.74 TRPV1 (0.46) SLC6A4ALDH1A1TSHRKIF11HAO1
SCHEMBL12807849 0.74 TSHR (0.42) ARSLC6A4ALDH1A1TSHRKDM4E
SCHEMBL19540477 0.74 TSHR (0.42) SLC6A4ALDH1A1TSHRKDM4EHSD17B10
SCHEMBL13299827 0.74 ALDH1A1 (0.50) SLC6A4ALDH1A1TSHRKIF11SLC6A2
SCHEMBL21100519 0.74 SLC6A4 (0.48) ARSLC6A4ALDH1A1TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007064869-A2 CATALYSTS FOR ARYL SULFIDE SYNTHESIS AND METHOD OF PRODUCING ARYL SULFIDES YALE UNIVERSITY (US) 2007-06-07 WO disclosed
WO-2007064869-A2 CATALYSTS FOR ARYL SULFIDE SYNTHESIS AND METHOD OF PRODUCING ARYL SULFIDES YALE UNIVERSITY (US) 2007-06-07 WO disclosed