SCHEMBL7014603

SCHEMBL7014603

FC(F)(F)Sc1ccc(C(F)(F)F)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.58
KDM4E B2RXH2 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
PTPRZ1 P23471 4/20 0.50
PTPN1 P18031 2/20 0.50
TSHR P16473 1/20 0.43
TRPV1 Q8NER1 1/20 0.43
KIF11 P52732 5/20 0.42
HAO1 Q9UJM8 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
ORAI1 Q96D31 1/20 0.41
ORAI2 Q96SN7 1/20 0.41
ORAI3 Q9BRQ5 1/20 0.41
TRPV6 Q9H1D0 1/20 0.41
MGLL Q99685 1/20 0.41
EPHX2 P34913 1/20 0.40
NR1H4 Q96RI1 1/20 0.40
FBP1 P09467 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5340454 0.80 AR (0.46) ALDH1A1KDM4ETDP1TSHRTRPV1
SCHEMBL10145012 0.80 TRPV1 (0.62) ALDH1A1KDM4ETDP1PTPRZ1PTPN1
SCHEMBL2417142 0.78 HAO1 (0.53) ALDH1A1TSHRKIF11HAO1CES2
SCHEMBL944341 0.78 FBP1 (0.57) ALDH1A1TSHRKIF11HAO1CES2
SCHEMBL24901392 0.77 MLYCD (0.58) ALDH1A1KDM4ETDP1PTPRZ1PTPN1
SCHEMBL63468 0.76 ALDH1A1 (0.67) ALDH1A1TSHRKIF11CES2CES1
Fluoride SCHEMBL29094698 0.76 HAO1 (0.52) ALDH1A1TSHRKIF11HAO1CES2
SCHEMBL7940607 0.76 ALDH1A1 (0.61) ALDH1A1KDM4ETDP1PTPRZ1PTPN1
SCHEMBL10978325 0.76 ALDH1A1 (0.61) ALDH1A1KDM4ETDP1PTPRZ1PTPN1
SCHEMBL19996403 0.76 CES2 (0.48) ALDH1A1PTPN1TSHRKIF11HAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-218793885-U Trifluoromethylthio-benzotrifluoride recycling device 江苏永创医药科技股份有限公司 2023-04-07 CN disclosed
EP-0962450-B1 Process for the preparation of perfluoalkylaryl sulfides BAYER AG (DE) 2003-01-08 EP disclosed
US-6175042-B1 A CHEMICAL INTERMEDIATE FOR AGROCHEMICALS, PHARMACEUTICALS, DYES, AND POLYMERS BAYER AKTIENGESELLSCHAFT (DE) 2001-01-16 US disclosed
EP-0962450-A1 Process for the preparation of perfluoalkylaryl sulfides and perfluoroalkylaryl sulfides per se Bayer Aktiengesellschaft (DE) 1999-12-08 EP disclosed