Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.55 |
| ▸ | ATIC | P31939 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315898 | 0.87 | KDM4E (0.64) | KDM4EL3MBTL1ATICALDH1A1BDKRB1 | |
| SCHEMBL5318602 | 0.85 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5315936 | 0.84 | KMT2A (0.58) | KDM4EL3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL5316738 | 0.84 | MEN1 (0.60) | KDM4EL3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL1203341 | 0.79 | PTK2 (0.54) | — | |
| SCHEMBL5318662 | 0.79 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6074331 | 0.77 | HDAC3 (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19345939 | 0.75 | ATIC (0.64) | KDM4EL3MBTL1ATICALDH1A1AKT1 | |
| SCHEMBL773314 | 0.75 | ALDH1A1 (0.68) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14579505 | 0.74 | HDAC3 (0.64) | KDM4EHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067993-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |