Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 9/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31661280 | 0.81 | HCAR3 (0.64) | GSK3BHCAR3NNMTPTPN1HCAR2 | |
| SCHEMBL16865853 | 0.81 | HCAR3 (0.64) | GSK3BHCAR3NNMTPTPN1HCAR2 | |
| SCHEMBL731875 | 0.81 | HCAR3 (0.64) | HCAR3HCAR2 | |
| Bromide SCHEMBL16753536 | 0.80 | HCAR3 (0.62) | GSK3BHCAR3NNMTPTPN1HCAR2 | |
| SCHEMBL1877716 | 0.80 | NNMT (0.65) | HCAR3NNMT | |
| SCHEMBL16048631 | 0.78 | MAPK1 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1203341 | 0.78 | PTK2 (0.54) | GSK3BHCAR3NNMTPTPN1 | |
| SCHEMBL31661260 | 0.78 | HCAR3 (0.69) | GSK3BHCAR3NNMTPTPN1HCAR2 | |
| SCHEMBL5340574 | 0.77 | KDM4E (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL16076748 | 0.77 | HPGD (0.62) | HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022716-B2 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH (US) | 2006-04-04 | — | — | US | disclosed |
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2003-07-31 | — | — | US | disclosed |
| US-6525202-B2 | E.g., substituted (4-amino-5-hydroxyphenyl)-oxy-)piperidinyl thiazolidin-2,4-dione; antidiabetic agents; atherosclerosis, gastrointestinal, metabolic disorders, glaucoma, neurogenetic inflammation, ocular hypertension and frequent urination | WYETH | 2003-02-25 | — | — | US | disclosed |
| US-20020028835-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | HDAC3 2186/4885HDAC4 2610/4885HDAC1 2422/4885 |
| US-20020028835-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | HDAC3 2186/4885HDAC4 2610/4885HDAC1 2422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.