Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.59 |
| ▸ | BACE1 | P56817 | 3/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HTR5A | P47898 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5563711 | 0.81 | SMN1; SMN2 (0.72) | CHEK1ALDH1A1MAPTSMN1; SMN2USP2 | |
| SCHEMBL2582475 | 0.80 | CHRNB2 (0.61) | ALDH1A1MAPTSMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL1173912 | 0.79 | NPY2R (0.65) | BACE1HTTMAPT | |
| SCHEMBL532949 | 0.78 | L3MBTL1 (0.59) | HTTALDH1A1MAPTSMN1; SMN2CHRNB2 | |
| SCHEMBL1646808 | 0.77 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL14328558 | 0.76 | CHEK1 (0.78) | CHEK1 | |
| SCHEMBL27684818 | 0.76 | CHRNB2 (0.50) | HTR6HTR1AHTR2AHTR7HTR5A | |
| SCHEMBL7841604 | 0.76 | ALDH1A1 (0.54) | CHEK1BACE1HTR6HTR1AHTR2A | |
| SCHEMBL7537046 | 0.76 | CHEK1 (0.54) | CHEK1HTR6MAPTL3MBTL1NPSR1 | |
| SCHEMBL11984490 | 0.75 | GSK3B (0.76) | CHEK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077457-A9 | TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS | ROYAL VETERINARY COLLEGE (GB) | 2007-10-18 | — | — | WO | disclosed |