SCHEMBL534322

SCHEMBL534322

CC(C)(Cc1cccc(C(N)(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1)OC(=O)NC(C(=O)O)C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTGER2 P43116 16/20 0.41
ADAMTS4 O75173 1/20 0.35
BCL2 P10415 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL533797 0.92 PTGER2 (0.36) PTGER2
SCHEMBL3458702 0.87 PTGER2 (0.46) PTGER2
SCHEMBL11023980 0.83 PTGER2 (0.59) PTGER2
SCHEMBL3459169 0.79 PTGER2 (0.41) PTGER2
SCHEMBL533750 0.79 USP2 (0.31)
SCHEMBL3459925 0.76 PTGER2 (0.53) PTGER2
SCHEMBL534324 0.75 PTGER2 (0.38) PTGER2ADAMTS4
SCHEMBL534323 0.74 PTGER2 (0.37) PTGER2ADAMTS4
SCHEMBL534415 0.73 CTSS (0.36) PTGER2
Hydrochloric Acid SCHEMBL534378 0.73 PTGER2 (0.61) PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8648097-B2 Pyridylaminoacetic acid compound UBE INDUSTRIES, LTD. (JP) 2014-02-11 US disclosed
EP-2415763-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA Ube Industries, Ltd. (JP) 2012-02-08 EP disclosed