Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | IGF1R | P08069 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.50 |
| ▸ | FLT1 | P17948 | 3/20 | 0.50 |
| ▸ | FLT4 | P35916 | 3/20 | 0.50 |
| ▸ | TEK | Q02763 | 3/20 | 0.50 |
| ▸ | PRKCB | P05771 | 5/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.47 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CCND1 | P24385 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | PRKCA | P17252 | 4/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.47 |
| ▸ | PRKACA | P17612 | 3/20 | 0.47 |
| ▸ | PRKACG | P22612 | 3/20 | 0.47 |
| ▸ | PRKACB | P22694 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.47 |
| ▸ | PRKCH | P24723 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349364 | 0.91 | CDK4 (0.54) | KDRIGF1RPDGFRBKITPDGFRA | |
| SCHEMBL5340128 | 0.84 | SIRT2 (0.50) | KDRIGF1RPDGFRBKITPDGFRA | |
| SCHEMBL7826159 | 0.81 | KDR (0.68) | KDRIGF1RPDGFRBKITPDGFRA | |
| SCHEMBL7824736 | 0.80 | PRKCB (0.74) | KDRIGF1RPDGFRBKITPDGFRA | |
| SCHEMBL5333621 | 0.78 | PRKCB (0.59) | KDRIGF1RPDGFRBKITPDGFRA | |
| SCHEMBL5334873 | 0.76 | SIRT2 (0.50) | CDK4CCND1CDK2CCNE2PRKACA | |
| SCHEMBL27716791 | 0.76 | GPR84 (0.34) | — | |
| SCHEMBL3144303 | 0.74 | GSK3B (0.62) | KDRIGF1RPDGFRBKITPDGFRA | |
| SCHEMBL9087145 | 0.72 | PRKCB (0.74) | KDRIGF1RPDGFRBKITPDGFRA | |
| SCHEMBL5344287 | 0.72 | KDR (0.58) | KDRIGF1RPDGFRBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202255-B2 | Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-04-10 | — | — | US | disclosed |
| EP-1587810-B1 | NOVEL SUBSTITUTED 1,4|BENZODIOXINO 2,3-E|ISOINDOLE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2006-11-08 | — | — | EP | disclosed |
| US-20060040930-A1 | Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-02-23 | — | — | US | disclosed |
| EP-1587810-A1 | NOVEL SUBSTITUTED 1,4]BENZODIOXINO 2,3-E]ISOINDOLE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004037831-A1 | NOVEL SUBSTITUTED[1,4]BENZODIOXINO[2,3-E]ISOINDOLE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040930-A1 | Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same | CYP11B2, CYP2F1, CYP3A43 | KDR 4318/4885IGF1R 1202/4885PDGFRB 2391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.