Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | NAT1 | P18440 | 5/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344157 | 1.00 | DNM1 (0.48) | DNM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL5342147 | 0.78 | CSNK2A2 (0.61) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL5342146 | 0.78 | CSNK2A2 (0.61) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A | |
| SCHEMBL5336100 | 0.77 | DNM1 (0.59) | DNM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL5336102 | 0.77 | DNM1 (0.59) | DNM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL2796664 | 0.76 | NR3C2 (0.41) | ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL5341980 | 0.76 | DNM1 (0.51) | DNM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL5341982 | 0.76 | DNM1 (0.51) | DNM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL5396619 | 0.76 | MEN1 (0.60) | DNM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL5340064 | 0.74 | PDE4B (0.63) | CSNK2A2CLK1CSNK2BCSNK2A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205295-B2 | Benzoxazin-3-ones and derivatives thereof as therapeutic agents | WARNER-LAMBERT COMPANY LLC (US) | 2007-04-17 | — | — | US | disclosed |
| EP-1569653-A1 | BENZOXAZIN-3-ONES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3K | Warner-Lambert Company LLC (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052373-A1 | BENZOXAZIN-3-ONES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3K | WARNER-LAMBERT COMPANY LLC (US) | 2004-06-24 | — | — | WO | disclosed |
| US-20040121996-A1 | Benzoxazin-3-ones and derivatives thereof as therapeutic agents | BARVIAN NICOLE (US) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121996-A1 | Benzoxazin-3-ones and derivatives thereof as therapeutic agents | XDH, HAX1, CYP4X1 | DNM1 4688/4885CSNK2A2 1028/4885CLK1 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.