Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 19/20 | 0.38 |
| ▸ | TPO | P07202 | 18/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536713 | 0.84 | ALDH1A1 (0.42) | OPRM1 | |
| SCHEMBL1536751 | 0.83 | MPO (0.47) | MPOTPOKCNH2OPRM1CYP3A4 | |
| SCHEMBL1536842 | 0.68 | MAPT (0.65) | — | |
| SCHEMBL1536633 | 0.68 | ALDH1A1 (0.48) | — | |
| SCHEMBL1536749 | 0.64 | MPO (0.61) | MPOTPOKCNH2OPRM1CYP3A4 | |
| SCHEMBL1536767 | 0.63 | NUDT1 (0.45) | — | |
| SCHEMBL1536763 | 0.60 | ALDH1A1 (0.39) | — | |
| SCHEMBL1536617 | 0.60 | MAPK8 (0.41) | — | |
| SCHEMBL1536665 | 0.59 | MPO (0.55) | MPOTPOKCNH2OPRM1CYP3A4 | |
| SCHEMBL18557963 | 0.59 | KMT2A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824855-A1 | NOVEL PYRROLO [3, 2-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY | AstraZeneca AB (SE) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006062465-A1 | NOVEL PYRROLO [3, 2-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-06-15 | — | — | WO | disclosed |