Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.61 |
| ▸ | EDNRB | P24530 | 3/20 | 0.61 |
| ▸ | BRD4 | O60885 | 8/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383562 | 0.82 | BRD4 (0.70) | EDNRAEDNRBBRD4TP53MAPT | |
| SCHEMBL5345756 | 0.80 | HSD11B1 (0.52) | EDNRAEDNRBHSD11B1HIF1ATP53 | |
| SCHEMBL5339534 | 0.79 | EDNRA (0.52) | EDNRAEDNRBHSD11B1HIF1A | |
| SCHEMBL21641912 | 0.77 | KAT6A (0.58) | EDNRAEDNRBBRD4HSD11B1TP53 | |
| SCHEMBL29652487 | 0.77 | KAT6A (0.58) | EDNRAEDNRBBRD4HSD11B1TP53 | |
| SCHEMBL618236 | 0.77 | PTPN1 (0.59) | EDNRAEDNRBHSD11B1 | |
| SCHEMBL7860462 | 0.76 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL5337088 | 0.76 | HSD11B1 (0.50) | EDNRAEDNRBBRD4HSD11B1HIF1A | |
| SCHEMBL5338606 | 0.76 | HSD11B1 (0.55) | EDNRAEDNRBHSD11B1MAPT | |
| SCHEMBL5343634 | 0.76 | EDNRB (0.53) | EDNRAEDNRBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | EDNRA 609/4885EDNRB 396/4885BRD4 2272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.