Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.52 |
| ▸ | EDNRB | P24530 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.51 |
| ▸ | CCR4 | P51679 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5337088 | 0.81 | HSD11B1 (0.50) | EDNRAEDNRBHSD11B1CCR4MEN1 | |
| SCHEMBL5341294 | 0.80 | ALPL (0.55) | EDNRAEDNRBALDH1A1HPGD | |
| SCHEMBL5344480 | 0.79 | EDNRA (0.61) | EDNRAEDNRBHSD11B1HIF1A | |
| SCHEMBL618236 | 0.79 | PTPN1 (0.59) | EDNRAEDNRBHSD11B1PTPN2PTPN1 | |
| SCHEMBL31234520 | 0.78 | PTPN1 (0.58) | MEN1KMT2ASLC40A1PTPN2PTPN1 | |
| SCHEMBL5347991 | 0.77 | MEN1 (0.78) | HSD11B1MEN1KMT2ASLC40A1ALDH1A1 | |
| SCHEMBL618169 | 0.77 | HSD11B1 (0.51) | EDNRAEDNRBHSD11B1CCR4MEN1 | |
| SCHEMBL5343689 | 0.76 | HSD11B1 (0.60) | EDNRAEDNRBHSD11B1CCR4MEN1 | |
| SCHEMBL5338742 | 0.76 | HSD11B1 (0.50) | EDNRAEDNRBHSD11B1CCR4MEN1 | |
| SCHEMBL5344543 | 0.76 | HSD11B1 (0.50) | EDNRAEDNRBHSD11B1CCR4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | EDNRA 609/4885EDNRB 396/4885HSD11B1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.