Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793470 | 0.88 | PDK1 (0.39) | METRPS6KB1MAPTMEN1KMT2A | |
| SCHEMBL5184529 | 0.87 | MAPT (0.53) | RPS6KB1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3793464 | 0.87 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3802829 | 0.84 | PDK1 (0.42) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL3796833 | 0.83 | MAPT (0.41) | RPS6KB1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3803929 | 0.82 | MAPT (0.43) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL3802381 | 0.82 | MAPT (0.45) | METCDK9MAPTMEN1KMT2A | |
| SCHEMBL3800865 | 0.81 | MAPT (0.54) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL3792949 | 0.80 | MAPT (0.53) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL5335832 | 0.79 | MAPT (0.46) | MAPTMEN1KMT2AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332602-B2 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332602-B2 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070155966-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | RIGEL PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| US-20070155966-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | RIGEL PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| US-7157473-B2 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040127497-A1 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | MIDCAP FINANCIAL TRUST | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127497-A1 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection | HAVCR2, HCCS, NQO1 | MET 1110/4885RPS6KB1 3114/4885CDK9 440/4885 |
| US-20070155966-A1 | Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection | HAVCR2, HCCS, NQO1 | MET 847/4885RPS6KB1 2815/4885CDK9 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.